PEACHi
GeneSet HIV_human_PPI_All (HIV_Collection.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--a -2.6 0.0337 290.0 58.0 41.19
DownRegulated -6.3 1.0E-5 290.0 210.0 171.26
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000135776 ABCB10 o++b
ENSG00000117528 ABCD3 NonAssociatedWithProgression
ENSG00000182827 ACBD3 NonAssociatedWithProgression
ENSG00000107897 ACBD5 o--b
ENSG00000101473 ACOT8 ---
ENSG00000123983 ACSL3 NonAssociatedWithProgression
ENSG00000172493 AFF1 +-o
ENSG00000072364 AFF4 NonAssociatedWithProgression
ENSG00000018510 AGPS ---
ENSG00000101444 AHCY o--a
ENSG00000168710 AHCYL1 -+o
ENSG00000158467 AHCYL2 -o-
ENSG00000164022 AIMP1 o++b
ENSG00000106305 AIMP2 NonAssociatedWithProgression
ENSG00000011243 AKAP8L ---
ENSG00000127914 AKAP9 NonAssociatedWithProgression
ENSG00000116127 ALMS1 NonAssociatedWithProgression
ENSG00000153107 ANAPC1 o--a
ENSG00000176248 ANAPC2 NonAssociatedWithProgression
ENSG00000131503 ANKHD1 o--b
ENSG00000076513 ANKRD13A o-o
ENSG00000132466 ANKRD17 ---
ENSG00000072958 AP1M1 o--b
ENSG00000142192 APP o++b
ENSG00000066777 ARFGEF1 NonAssociatedWithProgression
ENSG00000124198 ARFGEF2 o+o
ENSG00000141480 ARRB2 ---
ENSG00000197785 ATAD3A o--a
ENSG00000160072 ATAD3B o--a
ENSG00000184743 ATL3 o+o
ENSG00000174437 ATP2A2 -o-
ENSG00000074370 ATP2A3 o--b
ENSG00000070961 ATP2B1 +-o
ENSG00000110955 ATP5B o--b
ENSG00000099624 ATP5D o--a
ENSG00000116459 ATP5F1 NonAssociatedWithProgression
ENSG00000154723 ATP5J o+o
ENSG00000241837 ATP5O +o+
ENSG00000130638 ATXN10 o--b
ENSG00000185825 BCAP31 ---
ENSG00000185963 BICD2 --o
ENSG00000166167 BTRC --o
ENSG00000101084 C20orf24 o+o
ENSG00000179218 CALR ---
ENSG00000128595 CALU o--b
ENSG00000144712 CAND2 NonAssociatedWithProgression
ENSG00000127022 CANX NonAssociatedWithProgression
ENSG00000014216 CAPN1 ---
ENSG00000108349 CASC3 o-o
ENSG00000067955 CBFB o--a
ENSG00000108588 CCDC47 o++b
ENSG00000143702 CEP170 NonAssociatedWithProgression
ENSG00000166037 CEP57 NonAssociatedWithProgression
ENSG00000159259 CHAF1B o-o
ENSG00000172586 CHCHD1 NonAssociatedWithProgression
ENSG00000064886 CHI3L2 -+o
ENSG00000144021 CIAO1 -+o
ENSG00000136026 CKAP4 NonAssociatedWithProgression
ENSG00000153132 CLGN oo+
ENSG00000128973 CLN6 ---
ENSG00000093010 COMT NonAssociatedWithProgression
ENSG00000166200 COPS2 o--b
ENSG00000141030 COPS3 o--b
ENSG00000138663 COPS4 o+o
ENSG00000121022 COPS5 NonAssociatedWithProgression
ENSG00000168090 COPS6 ---
ENSG00000198612 COPS8 NonAssociatedWithProgression
ENSG00000131143 COX4I1 NonAssociatedWithProgression
ENSG00000178741 COX5A o--a
ENSG00000126267 COX6B1 NonAssociatedWithProgression
ENSG00000009307 CSDE1 o--b
ENSG00000204435 CSNK2B o--a
ENSG00000164733 CTSB --o
ENSG00000117984 CTSD NonAssociatedWithProgression
ENSG00000055130 CUL1 o++a
ENSG00000108094 CUL2 o+o
ENSG00000139842 CUL4A oo-
ENSG00000166266 CUL5 o--b
ENSG00000159348 CYB5R1 o--b
ENSG00000164535 DAGLB ---
ENSG00000115866 DARS NonAssociatedWithProgression
ENSG00000100897 DCAF11 o-o
ENSG00000163257 DCAF16 +oo
ENSG00000132716 DCAF8 o-o
ENSG00000130311 DDA1 o--b
ENSG00000167986 DDB1 o--a
ENSG00000064703 DDX20 NonAssociatedWithProgression
ENSG00000105671 DDX49 o-o
ENSG00000110367 DDX6 o--b
ENSG00000116133 DHCR24 NonAssociatedWithProgression
ENSG00000131504 DIAPH1 o--b
ENSG00000090520 DNAJB11 NonAssociatedWithProgression
ENSG00000135924 DNAJB2 ---
ENSG00000102580 DNAJC3 NonAssociatedWithProgression
ENSG00000168259 DNAJC7 ---
ENSG00000129932 DOHH ---
ENSG00000115325 DOK1 o--a
ENSG00000173852 DPY19L1 -+o
ENSG00000178904 DPY19L3 NonAssociatedWithProgression
ENSG00000096696 DSP NonAssociatedWithProgression
ENSG00000077380 DYNC1I2 o+o
ENSG00000144635 DYNC1LI1 o--a
ENSG00000038358 EDC4 NonAssociatedWithProgression
ENSG00000116406 EDEM3 o--a
ENSG00000124802 EEF1E1 NonAssociatedWithProgression
ENSG00000055332 EIF2AK2 o--a
ENSG00000107581 EIF3A NonAssociatedWithProgression
ENSG00000106263 EIF3B o--a
ENSG00000184110 EIF3C o--b
ENSG00000100353 EIF3D o--a
ENSG00000104408 EIF3E +-o
ENSG00000130811 EIF3G ---
ENSG00000147677 EIF3H o+o
ENSG00000084623 EIF3I -o-
ENSG00000178982 EIF3K o+o
ENSG00000100129 EIF3L o-o
ENSG00000149100 EIF3M NonAssociatedWithProgression
ENSG00000149499 EML3 ---
ENSG00000149218 ENDOD1 oo+
ENSG00000136628 EPRS o--b
ENSG00000113719 ERGIC1 o--a
ENSG00000087502 ERGIC2 NonAssociatedWithProgression
ENSG00000125991 ERGIC3 ---
ENSG00000068912 ERLEC1 NonAssociatedWithProgression
ENSG00000196405 EVL NonAssociatedWithProgression
ENSG00000131558 EXOC4 o--a
ENSG00000234545 FAM133B NonAssociatedWithProgression
ENSG00000172366 FAM195A --o
ENSG00000119812 FAM98A o-+
ENSG00000110429 FBXO3 o+o
ENSG00000072803 FBXW11 o++b
ENSG00000066926 FECH NonAssociatedWithProgression
ENSG00000004478 FKBP4 ---
ENSG00000160688 FLAD1 o--b
ENSG00000154803 FLCN o++b
ENSG00000137312 FLOT1 --o
ENSG00000217128 FNIP1 NonAssociatedWithProgression
ENSG00000033170 FUT8 -+o
ENSG00000145907 G3BP1 ---
ENSG00000138757 G3BP2 NonAssociatedWithProgression
ENSG00000178950 GAK o--a
ENSG00000089597 GANAB o--a
ENSG00000152147 GEMIN6 o+o
ENSG00000142252 GEMIN7 o--b
ENSG00000196329 GIMAP5 o++a
ENSG00000090863 GLG1 o-+
ENSG00000130309 GLT25D1 o--a
ENSG00000136935 GOLGA1 o++b
ENSG00000113384 GOLPH3 o-o
ENSG00000160818 GPATCH4 NonAssociatedWithProgression
ENSG00000169727 GPS1 ---
ENSG00000132522 GPS2 ---
ENSG00000177885 GRB2 NonAssociatedWithProgression
ENSG00000084754 HADHA NonAssociatedWithProgression
ENSG00000138029 HADHB o-o
ENSG00000112855 HARS2 NonAssociatedWithProgression
ENSG00000128708 HAT1 NonAssociatedWithProgression
ENSG00000171720 HDAC3 ---
ENSG00000111906 HDDC2 -oo
ENSG00000119285 HEATR1 o--a
ENSG00000128731 HERC2 +o+
ENSG00000197409 HIST1H3D +-o
ENSG00000206503 HLA-A +-o
ENSG00000234745 HLA-B o-+
ENSG00000204525 HLA-C o-+
ENSG00000101294 HM13 o--b
ENSG00000096746 HNRNPH3 +-o
ENSG00000149084 HSD17B12 NonAssociatedWithProgression
ENSG00000166598 HSP90B1 NonAssociatedWithProgression
ENSG00000155304 HSPA13 o+o
ENSG00000173110 HSPA6 NonAssociatedWithProgression
ENSG00000120694 HSPH1 o+-
ENSG00000086758 HUWE1 o-o
ENSG00000149428 HYOU1 o--b
ENSG00000196305 IARS o--a
ENSG00000108622 ICAM2 NonAssociatedWithProgression
ENSG00000166411 IDH3A ---
ENSG00000163913 IFT122 o--b
ENSG00000113141 IK o--a
ENSG00000196497 IPO4 o--b
ENSG00000198700 IPO9 o--b
ENSG00000115232 ITGA4 o--b
ENSG00000005844 ITGAL NonAssociatedWithProgression
ENSG00000160255 ITGB2 o--a
ENSG00000136156 ITM2B NonAssociatedWithProgression
ENSG00000116679 IVNS1ABP NonAssociatedWithProgression
ENSG00000065427 KARS o-o
ENSG00000127463 KIAA0090 NonAssociatedWithProgression
ENSG00000164944 KIAA1429 -o-
ENSG00000158941 KIAA1967 o--a
ENSG00000116685 KIAA2013 o--b
ENSG00000116852 KIF21B +oo
ENSG00000174720 LARP7 ---
ENSG00000133706 LARS NonAssociatedWithProgression
ENSG00000074695 LMAN1 o-o
ENSG00000169223 LMAN2 o--b
ENSG00000138095 LRPPRC NonAssociatedWithProgression
ENSG00000130764 LRRC47 NonAssociatedWithProgression
ENSG00000161654 LSM12 o--b
ENSG00000179222 MAGED1 NonAssociatedWithProgression
ENSG00000102158 MAGT1 o-+
ENSG00000069956 MAPK6 o+-
ENSG00000166986 MARS o--b
ENSG00000015479 MATR3 -o-
ENSG00000143384 MCL1 o-o
ENSG00000104738 MCM4 o--a
ENSG00000076003 MCM6 o--a
ENSG00000166508 MCM7 o--b
ENSG00000146834 MEPCE o--a
ENSG00000158411 MITD1 -+o
ENSG00000169446 MMGT1 o-o
ENSG00000115275 MOGS o-o
ENSG00000103152 MPG o--a
ENSG00000174547 MRPL11 ---
ENSG00000198015 MRPL42 o--a
ENSG00000147586 MRPS28 o+o
ENSG00000135972 MRPS9 o+o
ENSG00000124532 MRS2 -o-
ENSG00000095002 MSH2 +oo
ENSG00000147065 MSN NonAssociatedWithProgression
ENSG00000137409 MTCH1 NonAssociatedWithProgression
ENSG00000109919 MTCH2 o-o
ENSG00000065911 MTHFD2 +-o
ENSG00000205531 NAP1L4 ---
ENSG00000137513 NARS2 NonAssociatedWithProgression
ENSG00000151503 NCAPD3 o--b
ENSG00000141027 NCOR1 NonAssociatedWithProgression
ENSG00000140990 NDUFB10 -o-
ENSG00000110717 NDUFS8 o--a
ENSG00000102908 NFAT5 o--b
ENSG00000169599 NFU1 --o
ENSG00000151092 NGLY1 o+o
ENSG00000100138 NHP2L1 NonAssociatedWithProgression
ENSG00000136448 NMT1 o--b
ENSG00000166197 NOLC1 o--b
ENSG00000107833 NPM3 NonAssociatedWithProgression
ENSG00000090273 NUDC o--a
ENSG00000138430 OLA1 o+o
ENSG00000135506 OS9 o++b
ENSG00000070882 OSBPL3 NonAssociatedWithProgression
ENSG00000185624 P4HB o--a
ENSG00000102699 PARP4 o+o
ENSG00000167004 PDIA3 o--a
ENSG00000155660 PDIA4 ---
ENSG00000065485 PDIA5 NonAssociatedWithProgression
ENSG00000143870 PDIA6 o-o
ENSG00000152684 PELO o+o
ENSG00000101856 PGRMC1 o-o
ENSG00000167085 PHB NonAssociatedWithProgression
ENSG00000215021 PHB2 ---
ENSG00000150867 PIP4K2A NonAssociatedWithProgression
ENSG00000137055 PLAA o-o
ENSG00000083444 PLOD1 --o
ENSG00000188313 PLSCR1 o++b
ENSG00000177084 POLE o--b
ENSG00000148229 POLE3 o--a
ENSG00000105854 PON2 o++a
ENSG00000115241 PPM1G o--a
ENSG00000058272 PPP1R12A o+o
ENSG00000104695 PPP2CB +o+
ENSG00000154001 PPP2R5E o-o
ENSG00000123131 PRDX4 o--a
ENSG00000138073 PREB o--a
ENSG00000130175 PRKCSH o--b
ENSG00000253729 PRKDC o--b
ENSG00000126457 PRMT1 o--b
ENSG00000164985 PSIP1 o-o
ENSG00000129084 PSMA1 o--a
ENSG00000142507 PSMB6 o-o
ENSG00000108671 PSMD11 NonAssociatedWithProgression
ENSG00000131467 PSME3 o-o
ENSG00000110958 PTGES3 o--b
ENSG00000074696 PTPLAD1 o-o
ENSG00000055917 PUM2 o-o
ENSG00000172053 QARS o--b
ENSG00000011454 RABGAP1 o--a
ENSG00000099901 RANBP1 NonAssociatedWithProgression
ENSG00000153201 RANBP2 o+o
ENSG00000137040 RANBP6 o--a
ENSG00000113643 RARS NonAssociatedWithProgression
ENSG00000102054 RBBP7 o-o
ENSG00000134453 RBM17 NonAssociatedWithProgression
ENSG00000049449 RCN1 o-+
ENSG00000117906 RCN2 NonAssociatedWithProgression
ENSG00000004700 RECQL NonAssociatedWithProgression
ENSG00000157916 RER1 -+o
ENSG00000155366 RHOC --o
ENSG00000070423 RNF126 o--a
ENSG00000173821 RNF213 -o-
ENSG00000204308 RNF5 o--b
ENSG00000114125 RNF7 o+o
ENSG00000023191 RNH1 o--a
ENSG00000163902 RPN1 o-o
ENSG00000171848 RRM2 o--a
ENSG00000133318 RTN3 o--a
ENSG00000115310 RTN4 +oo
ENSG00000175792 RUVBL1 ---
ENSG00000031698 SARS NonAssociatedWithProgression
ENSG00000116521 SCAMP3 o--a
ENSG00000137575 SDCBP oo-
ENSG00000054282 SDCCAG8 ---
ENSG00000132581 SDF2 NonAssociatedWithProgression
ENSG00000128228 SDF2L1 o--a
ENSG00000078808 SDF4 ---
ENSG00000073578 SDHA o-o
ENSG00000058262 SEC61A1 ---
ENSG00000008952 SEC62 o--a
ENSG00000085415 SEH1L o-o
ENSG00000109618 SEPSECS o-o
ENSG00000149257 SERPINH1 --o
ENSG00000183431 SF3A3 NonAssociatedWithProgression
ENSG00000096717 SIRT1 +-o
ENSG00000113558 SKP1 ---
ENSG00000162695 SLC30A7 o+o
ENSG00000109062 SLC9A3R1 o--a
ENSG00000070366 SMG6 ---
ENSG00000172062 SMN1 NonAssociatedWithProgression
ENSG00000205571 SMN2 NonAssociatedWithProgression
ENSG00000122692 SMU1 -oo
ENSG00000129128 SPCS3 ---
ENSG00000161011 SQSTM1 ---
ENSG00000167978 SRRM2 o--a
ENSG00000106028 SSBP1 o++b
ENSG00000180879 SSR4 ---
ENSG00000173465 SSSCA1 NonAssociatedWithProgression
ENSG00000165283 STOML2 ---
ENSG00000023734 STRAP o--b
ENSG00000103266 STUB1 ---
ENSG00000136143 SUCLA2 -+o
ENSG00000129103 SUMF2 NonAssociatedWithProgression
ENSG00000164828 SUN1 o--a
ENSG00000148248 SURF4 o--b
ENSG00000055208 TAB2 o--b
ENSG00000113407 TARS NonAssociatedWithProgression
ENSG00000121749 TBC1D15 o+o
ENSG00000177565 TBL1XR1 o-o
ENSG00000136270 TBRG4 o--a
ENSG00000154582 TCEB1 NonAssociatedWithProgression
ENSG00000103363 TCEB2 o--a
ENSG00000054118 THRAP3 o--a
ENSG00000066654 THUMPD1 o++b
ENSG00000099800 TIMM13 o--a
ENSG00000126953 TIMM8A NonAssociatedWithProgression
ENSG00000150779 TIMM8B --o
ENSG00000170348 TMED10 --o
ENSG00000158604 TMED4 +o+
ENSG00000184840 TMED9 NonAssociatedWithProgression
ENSG00000178307 TMEM11 ---
ENSG00000130748 TMEM160 o-o
ENSG00000095209 TMEM38B NonAssociatedWithProgression
ENSG00000170876 TMEM43 NonAssociatedWithProgression
ENSG00000130204 TOMM40 o--a
ENSG00000136827 TOR1A NonAssociatedWithProgression
ENSG00000169905 TOR1AIP2 NonAssociatedWithProgression
ENSG00000173113 TRMT112 --o
ENSG00000078246 TULP3 o--a
ENSG00000239264 TXNDC5 o--b
ENSG00000130985 UBA1 o--b
ENSG00000175931 UBE2O NonAssociatedWithProgression
ENSG00000102178 UBL4A o--a
ENSG00000024048 UBR2 o++a
ENSG00000127481 UBR4 o-o
ENSG00000136731 UGGT1 NonAssociatedWithProgression
ENSG00000140553 UNC45A -o-
ENSG00000102226 USP11 o-o
ENSG00000101558 VAPA NonAssociatedWithProgression
ENSG00000155959 VBP1 o+-
ENSG00000165280 VCP o+-
ENSG00000213585 VDAC1 --o
ENSG00000165637 VDAC2 -o-
ENSG00000078668 VDAC3 -+o
ENSG00000151532 VTI1A +oo
ENSG00000140395 WDR61 o+o
ENSG00000082898 XPO1 o-o
ENSG00000132953 XPO4 o--b
ENSG00000124571 XPO5 o+o
ENSG00000166913 YWHAB o--b
ENSG00000108953 YWHAE NonAssociatedWithProgression
ENSG00000170027 YWHAG o+-
ENSG00000164924 YWHAZ o--b
ENSG00000186660 ZFP91 +-o
ENSG00000218891 ZNF579 o-o