PEACHi
GeneSet Disease (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--b -4.4 0.00382 343.0 73.0 47.39
o-o -2.6 0.02804 343.0 43.0 28.76
DownRegulated -5.4 1.0E-4 343.0 241.0 202.55
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000094914 AAAS o--a
ENSG00000072778 ACADVL o--b
ENSG00000075624 ACTB o--b
ENSG00000137845 ADAM10 NonAssociatedWithProgression
ENSG00000151694 ADAM17 +-o
ENSG00000138031 ADCY3 o-o
ENSG00000121281 ADCY7 -+o
ENSG00000087274 ADD1 +o+
ENSG00000173020 ADRBK1 o--b
ENSG00000142208 AKT1 ---
ENSG00000204673 AKT1S1 ---
ENSG00000105221 AKT2 o--a
ENSG00000117020 AKT3 o++b
ENSG00000100280 AP1B1 o--b
ENSG00000166747 AP1G1 o+-
ENSG00000072958 AP1M1 o--b
ENSG00000106367 AP1S1 ---
ENSG00000182287 AP1S2 -+o
ENSG00000196961 AP2A1 ---
ENSG00000006125 AP2B1 ---
ENSG00000161203 AP2M1 ---
ENSG00000042753 AP2S1 o--b
ENSG00000142192 APP o++b
ENSG00000143761 ARF1 o--b
ENSG00000102606 ARHGEF7 NonAssociatedWithProgression
ENSG00000162772 ATF3 +-o
ENSG00000128272 ATF4 o--b
ENSG00000118217 ATF6 o--a
ENSG00000159720 ATP6V0D1 o--a
ENSG00000047249 ATP6V1H o+o
ENSG00000166710 B2M o+o
ENSG00000175334 BANF1 o--b
ENSG00000114200 BCHE NonAssociatedWithProgression
ENSG00000166167 BTRC --o
ENSG00000074842 C19orf10 o-o
ENSG00000198668 CALM1 NonAssociatedWithProgression
ENSG00000179218 CALR ---
ENSG00000152495 CAMK4 +-o
ENSG00000127022 CANX NonAssociatedWithProgression
ENSG00000110395 CBL o--b
ENSG00000134480 CCNH -o-
ENSG00000082258 CCNT2 o-o
ENSG00000198821 CD247 NonAssociatedWithProgression
ENSG00000178562 CD28 o+o
ENSG00000010610 CD4 o--b
ENSG00000026508 CD44 o++b
ENSG00000105401 CDC37 ---
ENSG00000070831 CDC42 +oo
ENSG00000170312 CDK1 o-+
ENSG00000134058 CDK7 o+o
ENSG00000124762 CDKN1A oo-
ENSG00000111276 CDKN1B +o+
ENSG00000213341 CHUK NonAssociatedWithProgression
ENSG00000122705 CLTA +-o
ENSG00000141367 CLTC -o-
ENSG00000188986 COBRA1 o--b
ENSG00000160917 CPSF4 o--b
ENSG00000118260 CREB1 o+-
ENSG00000103653 CSK o--b
ENSG00000101439 CST3 --o
ENSG00000060069 CTDP1 ---
ENSG00000175215 CTDSP2 o-+
ENSG00000166266 CUL5 o--b
ENSG00000044090 CUL7 ---
ENSG00000121966 CXCR4 o--b
ENSG00000154832 CXXC1 o--a
ENSG00000172795 DCP2 o-o
ENSG00000204843 DCTN1 ---
ENSG00000175197 DDIT3 +-o
ENSG00000013573 DDX11 o--a
ENSG00000083520 DIS3 o--a
ENSG00000090520 DNAJB11 NonAssociatedWithProgression
ENSG00000128590 DNAJB9 o--b
ENSG00000102580 DNAJC3 NonAssociatedWithProgression
ENSG00000134516 DOCK2 o--a
ENSG00000134109 EDEM1 o--b
ENSG00000055332 EIF2AK2 o--a
ENSG00000172071 EIF2AK3 NonAssociatedWithProgression
ENSG00000134001 EIF2S1 o--a
ENSG00000105656 ELL o--a
ENSG00000155849 ELMO1 o+o
ENSG00000063245 EPN1 ---
ENSG00000085832 EPS15 +-o
ENSG00000127527 EPS15L1 ---
ENSG00000104884 ERCC2 ---
ENSG00000163161 ERCC3 o-o
ENSG00000197930 ERO1L ---
ENSG00000090989 EXOC1 o++b
ENSG00000112685 EXOC2 o++a
ENSG00000180104 EXOC3 o--b
ENSG00000131558 EXOC4 o--a
ENSG00000070367 EXOC5 NonAssociatedWithProgression
ENSG00000138190 EXOC6 o--b
ENSG00000182473 EXOC7 --o
ENSG00000171311 EXOSC1 NonAssociatedWithProgression
ENSG00000130713 EXOSC2 o--b
ENSG00000107371 EXOSC3 NonAssociatedWithProgression
ENSG00000178896 EXOSC4 --o
ENSG00000077348 EXOSC5 o--a
ENSG00000223496 EXOSC6 o--a
ENSG00000075914 EXOSC7 NonAssociatedWithProgression
ENSG00000123737 EXOSC9 o--b
ENSG00000012232 EXTL3 o-o
ENSG00000149806 FAU o-o
ENSG00000168496 FEN1 NonAssociatedWithProgression
ENSG00000106080 FKBP14 -+o
ENSG00000118689 FOXO3 NonAssociatedWithProgression
ENSG00000184481 FOXO4 --o
ENSG00000010810 FYN +oo
ENSG00000198380 GFPT1 NonAssociatedWithProgression
ENSG00000177885 GRB2 NonAssociatedWithProgression
ENSG00000132463 GRSF1 o--a
ENSG00000105723 GSK3A ---
ENSG00000082701 GSK3B -o-
ENSG00000140307 GTF2A2 NonAssociatedWithProgression
ENSG00000137947 GTF2B NonAssociatedWithProgression
ENSG00000153767 GTF2E1 o++b
ENSG00000197265 GTF2E2 NonAssociatedWithProgression
ENSG00000125651 GTF2F1 o--a
ENSG00000188342 GTF2F2 NonAssociatedWithProgression
ENSG00000110768 GTF2H1 o++b
ENSG00000145736 GTF2H2 o++b
ENSG00000111358 GTF2H3 NonAssociatedWithProgression
ENSG00000188486 H2AFX ---
ENSG00000164032 H2AFZ o-o
ENSG00000163041 H3F3A NonAssociatedWithProgression
ENSG00000143321 HDGF ---
ENSG00000051108 HERPUD1 +oo
ENSG00000185359 HGS o--b
ENSG00000137259 HIST1H2AB oo-
ENSG00000180573 HIST1H2AC NonAssociatedWithProgression
ENSG00000196226 HIST1H2BB o--b
ENSG00000158373 HIST1H2BD NonAssociatedWithProgression
ENSG00000197459 HIST1H2BH oo-
ENSG00000196176 HIST1H4A ---
ENSG00000183558 HIST2H2AA3 o--b
ENSG00000184678 HIST2H2BE NonAssociatedWithProgression
ENSG00000206503 HLA-A +-o
ENSG00000137309 HMGA1 o--b
ENSG00000174775 HRAS o--b
ENSG00000080824 HSP90AA1 NonAssociatedWithProgression
ENSG00000166598 HSP90B1 NonAssociatedWithProgression
ENSG00000204389 HSPA1A o--b
ENSG00000149428 HYOU1 o--b
ENSG00000073792 IGF2BP2 -oo
ENSG00000136231 IGF2BP3 o-+
ENSG00000115457 IGFBP2 o--b
ENSG00000115461 IGFBP5 NonAssociatedWithProgression
ENSG00000065150 IPO5 -o-
ENSG00000136156 ITM2B NonAssociatedWithProgression
ENSG00000150995 ITPR1 o++b
ENSG00000096433 ITPR3 o-o
ENSG00000088247 KHSRP o--b
ENSG00000170759 KIF5B NonAssociatedWithProgression
ENSG00000124702 KLHDC3 o--a
ENSG00000114030 KPNA1 NonAssociatedWithProgression
ENSG00000108424 KPNB1 o--a
ENSG00000133703 KRAS o+o
ENSG00000182866 LCK o-o
ENSG00000105486 LIG1 o--a
ENSG00000174405 LIG4 -+o
ENSG00000144749 LRIG1 -+o
ENSG00000169032 MAP2K1 NonAssociatedWithProgression
ENSG00000126934 MAP2K2 o--a
ENSG00000100030 MAPK1 NonAssociatedWithProgression
ENSG00000102882 MAPK3 o--b
ENSG00000119487 MAPKAP1 o--a
ENSG00000140943 MBTPS1 o++a
ENSG00000012174 MBTPS2 oo+
ENSG00000135679 MDM2 -o-
ENSG00000140545 MFGE8 o--a
ENSG00000167965 MLST8 o--a
ENSG00000198793 MTOR NonAssociatedWithProgression
ENSG00000136997 MYC o--b
ENSG00000197535 MYO5A NonAssociatedWithProgression
ENSG00000136937 NCBP1 o+-
ENSG00000114503 NCBP2 o--b
ENSG00000001167 NFYA NonAssociatedWithProgression
ENSG00000120837 NFYB o-o
ENSG00000066136 NFYC NonAssociatedWithProgression
ENSG00000136448 NMT1 o--b
ENSG00000152465 NMT2 NonAssociatedWithProgression
ENSG00000181163 NPM1 o--b
ENSG00000213281 NRAS o--b
ENSG00000111581 NUP107 -+o
ENSG00000069248 NUP133 o+-
ENSG00000124789 NUP153 o+-
ENSG00000113569 NUP155 NonAssociatedWithProgression
ENSG00000030066 NUP160 NonAssociatedWithProgression
ENSG00000095319 NUP188 ---
ENSG00000155561 NUP205 -o-
ENSG00000132182 NUP210 o-o
ENSG00000126883 NUP214 NonAssociatedWithProgression
ENSG00000163002 NUP35 oo-
ENSG00000075188 NUP37 NonAssociatedWithProgression
ENSG00000093000 NUP50 NonAssociatedWithProgression
ENSG00000138750 NUP54 o-o
ENSG00000213024 NUP62 o--a
ENSG00000125450 NUP85 o--b
ENSG00000108559 NUP88 NonAssociatedWithProgression
ENSG00000102900 NUP93 o-o
ENSG00000110713 NUP98 o--a
ENSG00000139496 NUPL1 +-o
ENSG00000136243 NUPL2 o+-
ENSG00000100836 PABPN1 o--a
ENSG00000175115 PACS1 ---
ENSG00000180370 PAK2 ---
ENSG00000140694 PARN o-o
ENSG00000123360 PDE1B o-+
ENSG00000065485 PDIA5 NonAssociatedWithProgression
ENSG00000143870 PDIA6 o-o
ENSG00000140992 PDPK1 -o-
ENSG00000081913 PHLPP1 NonAssociatedWithProgression
ENSG00000121879 PIK3CA +-o
ENSG00000145675 PIK3R1 o--a
ENSG00000122194 PLG o+o
ENSG00000181222 POLR2A ---
ENSG00000047315 POLR2B +oo
ENSG00000102978 POLR2C NonAssociatedWithProgression
ENSG00000144231 POLR2D o--b
ENSG00000100142 POLR2F NonAssociatedWithProgression
ENSG00000168002 POLR2G NonAssociatedWithProgression
ENSG00000163882 POLR2H o-o
ENSG00000105258 POLR2I --o
ENSG00000005075 POLR2J ---
ENSG00000177700 POLR2L o-o
ENSG00000196313 POM121 o--b
ENSG00000196262 PPIA NonAssociatedWithProgression
ENSG00000068971 PPP2R5B NonAssociatedWithProgression
ENSG00000138073 PREB o--a
ENSG00000072062 PRKACA ---
ENSG00000142875 PRKACB o--b
ENSG00000108946 PRKAR1A o+-
ENSG00000188191 PRKAR1B NonAssociatedWithProgression
ENSG00000154229 PRKCA oo+
ENSG00000163932 PRKCD NonAssociatedWithProgression
ENSG00000172179 PRL o++a
ENSG00000164985 PSIP1 o-o
ENSG00000129084 PSMA1 o--a
ENSG00000106588 PSMA2 o+o
ENSG00000100567 PSMA3 o+o
ENSG00000041357 PSMA4 -+o
ENSG00000143106 PSMA5 o--a
ENSG00000100902 PSMA6 NonAssociatedWithProgression
ENSG00000101182 PSMA7 -+o
ENSG00000008018 PSMB1 o-o
ENSG00000126067 PSMB2 oo-
ENSG00000108294 PSMB3 -+o
ENSG00000159377 PSMB4 NonAssociatedWithProgression
ENSG00000100804 PSMB5 o--b
ENSG00000142507 PSMB6 o-o
ENSG00000136930 PSMB7 NonAssociatedWithProgression
ENSG00000204264 PSMB8 o--b
ENSG00000240065 PSMB9 o-o
ENSG00000100764 PSMC1 NonAssociatedWithProgression
ENSG00000161057 PSMC2 o+o
ENSG00000165916 PSMC3 o-o
ENSG00000013275 PSMC4 NonAssociatedWithProgression
ENSG00000087191 PSMC5 -+o
ENSG00000100519 PSMC6 o+o
ENSG00000173692 PSMD1 NonAssociatedWithProgression
ENSG00000101843 PSMD10 o+o
ENSG00000108671 PSMD11 NonAssociatedWithProgression
ENSG00000197170 PSMD12 oo-
ENSG00000185627 PSMD13 o--b
ENSG00000115233 PSMD14 o+o
ENSG00000175166 PSMD2 ---
ENSG00000108344 PSMD3 ---
ENSG00000159352 PSMD4 NonAssociatedWithProgression
ENSG00000095261 PSMD5 o++b
ENSG00000163636 PSMD6 o+o
ENSG00000099341 PSMD8 o--b
ENSG00000110801 PSMD9 o--b
ENSG00000100911 PSME2 NonAssociatedWithProgression
ENSG00000131467 PSME3 o-o
ENSG00000068878 PSME4 o--b
ENSG00000125818 PSMF1 o-+
ENSG00000171862 PTEN NonAssociatedWithProgression
ENSG00000179295 PTPN11 NonAssociatedWithProgression
ENSG00000069974 RAB27A o++b
ENSG00000136238 RAC1 NonAssociatedWithProgression
ENSG00000101146 RAE1 -o-
ENSG00000132155 RAF1 NonAssociatedWithProgression
ENSG00000132341 RAN o--b
ENSG00000099901 RANBP1 NonAssociatedWithProgression
ENSG00000153201 RANBP2 o+o
ENSG00000100401 RANGAP1 o-o
ENSG00000100387 RBX1 o--a
ENSG00000180198 RCC1 o--a
ENSG00000204356 RDBP o-o
ENSG00000164327 RICTOR o--b
ENSG00000111880 RNGTT NonAssociatedWithProgression
ENSG00000101654 RNMT NonAssociatedWithProgression
ENSG00000147403 RPL10 o-o
ENSG00000198755 RPL10A NonAssociatedWithProgression
ENSG00000142676 RPL11 o--b
ENSG00000197958 RPL12 NonAssociatedWithProgression
ENSG00000167526 RPL13 o--b
ENSG00000142541 RPL13A NonAssociatedWithProgression
ENSG00000188846 RPL14 o--a
ENSG00000174748 RPL15 o--a
ENSG00000215472 RPL17 o-o
ENSG00000105640 RPL18A o-o
ENSG00000108298 RPL19 o-o
ENSG00000122026 RPL21 o--a
ENSG00000116251 RPL22 +-o
ENSG00000125691 RPL23 NonAssociatedWithProgression
ENSG00000198242 RPL23A o--a
ENSG00000114391 RPL24 o--b
ENSG00000161970 RPL26 o-o
ENSG00000131469 RPL27 NonAssociatedWithProgression
ENSG00000166441 RPL27A o--a
ENSG00000108107 RPL28 o--b
ENSG00000162244 RPL29 o--a
ENSG00000100316 RPL3 -o-
ENSG00000156482 RPL30 o++b
ENSG00000071082 RPL31 o-+
ENSG00000144713 RPL32 NonAssociatedWithProgression
ENSG00000109475 RPL34 NonAssociatedWithProgression
ENSG00000136942 RPL35 o--b
ENSG00000182899 RPL35A NonAssociatedWithProgression
ENSG00000130255 RPL36 o-o
ENSG00000241343 RPL36A ---
ENSG00000145592 RPL37 NonAssociatedWithProgression
ENSG00000197756 RPL37A NonAssociatedWithProgression
ENSG00000198918 RPL39 o-+
ENSG00000174444 RPL4 o--b
ENSG00000122406 RPL5 NonAssociatedWithProgression
ENSG00000089009 RPL6 o--b
ENSG00000147604 RPL7 NonAssociatedWithProgression
ENSG00000148303 RPL7A -o-
ENSG00000161016 RPL8 ---
ENSG00000163682 RPL9 NonAssociatedWithProgression
ENSG00000089157 RPLP0 o--b
ENSG00000137818 RPLP1 NonAssociatedWithProgression
ENSG00000177600 RPLP2 NonAssociatedWithProgression
ENSG00000124614 RPS10 NonAssociatedWithProgression
ENSG00000142534 RPS11 o--a
ENSG00000112306 RPS12 o--a
ENSG00000110700 RPS13 NonAssociatedWithProgression
ENSG00000164587 RPS14 -o-
ENSG00000115268 RPS15 NonAssociatedWithProgression
ENSG00000134419 RPS15A o+-
ENSG00000105193 RPS16 o--b
ENSG00000231500 RPS18 o-o
ENSG00000105372 RPS19 -o-
ENSG00000140988 RPS2 o--a
ENSG00000008988 RPS20 o--a
ENSG00000186468 RPS23 o-o
ENSG00000138326 RPS24 NonAssociatedWithProgression
ENSG00000197728 RPS26 NonAssociatedWithProgression
ENSG00000177954 RPS27 o-o
ENSG00000143947 RPS27A o+o
ENSG00000233927 RPS28 o-o
ENSG00000213741 RPS29 NonAssociatedWithProgression
ENSG00000149273 RPS3 o--b
ENSG00000145425 RPS3A o-o
ENSG00000198034 RPS4X NonAssociatedWithProgression
ENSG00000129824 RPS4Y1 o--a
ENSG00000083845 RPS5 o--a
ENSG00000137154 RPS6 o--a
ENSG00000175634 RPS6KB2 -o-
ENSG00000171863 RPS7 o--a
ENSG00000142937 RPS8 NonAssociatedWithProgression
ENSG00000170889 RPS9 o--b
ENSG00000168028 RPSA o--b
ENSG00000140612 SEC11A oo-
ENSG00000166562 SEC11C NonAssociatedWithProgression
ENSG00000138674 SEC31A o+o
ENSG00000085415 SEH1L o-o
ENSG00000120742 SERP1 --o
ENSG00000147010 SH3KBP1 +o+
ENSG00000160691 SHC1 o--a
ENSG00000113558 SKP1 ---
ENSG00000151729 SLC25A4 -oo
ENSG00000005022 SLC25A5 NonAssociatedWithProgression
ENSG00000169100 SLC25A6 o-o
ENSG00000145740 SLC30A5 o+o
ENSG00000152683 SLC30A6 NonAssociatedWithProgression
ENSG00000162695 SLC30A7 o+o
ENSG00000115904 SOS1 -+o
ENSG00000114902 SPCS1 o-o
ENSG00000129128 SPCS3 ---
ENSG00000164056 SPRY1 +o+
ENSG00000136158 SPRY2 o+o
ENSG00000182934 SRPR o--a
ENSG00000144867 SRPRB NonAssociatedWithProgression
ENSG00000124783 SSR1 -+o
ENSG00000149136 SSRP1 o--b
ENSG00000136738 STAM NonAssociatedWithProgression
ENSG00000115145 STAM2 o+o
ENSG00000104915 STX10 o--a
ENSG00000135604 STX11 o++b
ENSG00000117758 STX12 NonAssociatedWithProgression
ENSG00000124222 STX16 o--a
ENSG00000099365 STX1B NonAssociatedWithProgression
ENSG00000111450 STX2 +-o
ENSG00000166900 STX3 -+o
ENSG00000103496 STX4 o-o
ENSG00000162236 STX5 o--a
ENSG00000079950 STX7 o+o
ENSG00000170310 STX8 NonAssociatedWithProgression
ENSG00000213599 SULT1A3 o--b
ENSG00000092201 SUPT16H o--a
ENSG00000213246 SUPT4H1 o--a
ENSG00000196235 SUPT5H o--b
ENSG00000147133 TAF1 NonAssociatedWithProgression
ENSG00000166337 TAF10 o--a
ENSG00000064995 TAF11 o--b
ENSG00000120656 TAF12 o--a
ENSG00000197780 TAF13 o+o
ENSG00000130699 TAF4 o++b
ENSG00000141384 TAF4B NonAssociatedWithProgression
ENSG00000148835 TAF5 o--a
ENSG00000106290 TAF6 NonAssociatedWithProgression
ENSG00000085231 TAF9 o+o
ENSG00000157014 TATDN2 o--a
ENSG00000112592 TBP NonAssociatedWithProgression
ENSG00000187735 TCEA1 NonAssociatedWithProgression
ENSG00000154582 TCEB1 NonAssociatedWithProgression
ENSG00000103363 TCEB2 o--a
ENSG00000011007 TCEB3 NonAssociatedWithProgression
ENSG00000105329 TGFB1 o--a
ENSG00000101158 TH1L o--b
ENSG00000137076 TLN1 NonAssociatedWithProgression
ENSG00000166340 TPP1 o--a
ENSG00000047410 TPR o+-
ENSG00000101255 TRIB3 +-o
ENSG00000103197 TSC2 ---
ENSG00000074319 TSG101 NonAssociatedWithProgression
ENSG00000184205 TSPYL2 o--b
ENSG00000221983 UBA52 o--a
ENSG00000170315 UBB ---
ENSG00000139190 VAMP1 o++b
ENSG00000220205 VAMP2 o--b
ENSG00000160948 VPS28 o-o
ENSG00000155975 VPS37A +o+
ENSG00000139722 VPS37B o--b
ENSG00000185049 WHSC2 o--b
ENSG00000070540 WIPI1 o+o
ENSG00000100219 XBP1 -+o
ENSG00000082898 XPO1 o-o
ENSG00000152422 XRCC4 o++a
ENSG00000079246 XRCC5 -o-
ENSG00000196419 XRCC6 o--b
ENSG00000174851 YIF1A o--a
ENSG00000166913 YWHAB o--b
ENSG00000116809 ZBTB17 o--b
env_region env_region +o+
gag_region gag_region oo+
nef_region nef_region oo+
tat_region tat_region oo+
vif_region vif_region oo+
vpu_region vpu_region oo+