PEACHi
GeneSet DNA_BINDING (GO_-_Molecular_Function.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--b -4.9 0.0108 271.0 62.0 37.44
DownRegulated -3.2 0.02344 271.0 185.0 160.04
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000108270 AATF o--b
ENSG00000138443 ABI2 o-o
ENSG00000106624 AEBP1 ---
ENSG00000172493 AFF1 +-o
ENSG00000072364 AFF4 NonAssociatedWithProgression
ENSG00000100823 APEX1 NonAssociatedWithProgression
ENSG00000137074 APTX NonAssociatedWithProgression
ENSG00000117713 ARID1A o--b
ENSG00000049618 ARID1B o+o
ENSG00000032219 ARID4A o-+
ENSG00000143437 ARNT o++b
ENSG00000123268 ATF1 o--b
ENSG00000162772 ATF3 +-o
ENSG00000128272 ATF4 o--b
ENSG00000118217 ATF6 o--a
ENSG00000156273 BACH1 +oo
ENSG00000156127 BATF o++b
ENSG00000123685 BATF3 o--a
ENSG00000113916 BCL6 +-o
ENSG00000029363 BCLAF1 NonAssociatedWithProgression
ENSG00000171634 BPTF NonAssociatedWithProgression
ENSG00000012048 BRCA1 NonAssociatedWithProgression
ENSG00000106245 BUD31 -o-
ENSG00000197223 C1D NonAssociatedWithProgression
ENSG00000067955 CBFB o--a
ENSG00000110395 CBL o--b
ENSG00000151014 CCRN4L o--a
ENSG00000111328 CDK2AP1 --o
ENSG00000115816 CEBPZ o++a
ENSG00000145241 CENPC1 NonAssociatedWithProgression
ENSG00000163320 CGGBP1 NonAssociatedWithProgression
ENSG00000173575 CHD2 o--b
ENSG00000170004 CHD3 o--a
ENSG00000111642 CHD4 o--b
ENSG00000164442 CITED2 o++b
ENSG00000169714 CNBP o--a
ENSG00000198791 CNOT7 --o
ENSG00000118260 CREB1 o+-
ENSG00000146592 CREB5 +oo
ENSG00000005339 CREBBP NonAssociatedWithProgression
ENSG00000111269 CREBL2 o++b
ENSG00000008405 CRY1 NonAssociatedWithProgression
ENSG00000060138 CSDA -o-
ENSG00000102974 CTCF o--b
ENSG00000154832 CXXC1 o--a
ENSG00000167986 DDB1 o--a
ENSG00000134574 DDB2 o--a
ENSG00000158796 DEDD -o-
ENSG00000115844 DLX2 NonAssociatedWithProgression
ENSG00000013563 DNASE1L1 o-o
ENSG00000167968 DNASE1L2 o--a
ENSG00000105612 DNASE2 NonAssociatedWithProgression
ENSG00000119772 DNMT3A o-o
ENSG00000175550 DRAP1 o--b
ENSG00000101412 E2F1 o--b
ENSG00000112242 E2F3 NonAssociatedWithProgression
ENSG00000205250 E2F4 ---
ENSG00000107223 EDF1 o--b
ENSG00000120738 EGR1 NonAssociatedWithProgression
ENSG00000120690 ELF1 o--b
ENSG00000126767 ELK1 ---
ENSG00000134759 ELP2 ---
ENSG00000134014 ELP3 o+o
ENSG00000074800 ENO1 o--b
ENSG00000100393 EP300 o++b
ENSG00000175595 ERCC4 o-o
ENSG00000134899 ERCC5 NonAssociatedWithProgression
ENSG00000244405 ETV5 +-o
ENSG00000139083 ETV6 o++a
ENSG00000174371 EXO1 o++b
ENSG00000106462 EZH2 NonAssociatedWithProgression
ENSG00000168496 FEN1 NonAssociatedWithProgression
ENSG00000183900 FOXD1 o++b
ENSG00000141568 FOXK2 o--a
ENSG00000170802 FOXN2 -o-
ENSG00000118689 FOXO3 NonAssociatedWithProgression
ENSG00000184481 FOXO4 --o
ENSG00000162613 FUBP1 +oo
ENSG00000154727 GABPA o--b
ENSG00000143458 GABPB2 NonAssociatedWithProgression
ENSG00000007237 GAS7 ---
ENSG00000107485 GATA3 o+o
ENSG00000106571 GLI3 o++a
ENSG00000160007 GRLF1 +o+
ENSG00000115207 GTF3C2 NonAssociatedWithProgression
ENSG00000155115 GTF3C6 NonAssociatedWithProgression
ENSG00000180353 HCLS1 o--a
ENSG00000116478 HDAC1 ---
ENSG00000196591 HDAC2 NonAssociatedWithProgression
ENSG00000114315 HES1 NonAssociatedWithProgression
ENSG00000144485 HES6 ---
ENSG00000164683 HEY1 +o+
ENSG00000100644 HIF1A NonAssociatedWithProgression
ENSG00000100084 HIRA ---
ENSG00000010818 HIVEP2 NonAssociatedWithProgression
ENSG00000071794 HLTF ---
ENSG00000137309 HMGA1 o--b
ENSG00000149948 HMGA2 oo-
ENSG00000189403 HMGB1 o--b
ENSG00000164104 HMGB2 o--b
ENSG00000029993 HMGB3 o--b
ENSG00000205581 HMGN1 o+o
ENSG00000135486 HNRNPA1 o+-
ENSG00000122566 HNRNPA2B1 oo-
ENSG00000153187 HNRNPU o--b
ENSG00000152795 HNRPDL oo-
ENSG00000185122 HSF1 ---
ENSG00000025156 HSF2 o-o
ENSG00000086758 HUWE1 o-o
ENSG00000163565 IFI16 o--a
ENSG00000132740 IGHMBP2 ---
ENSG00000070061 IKBKAP NonAssociatedWithProgression
ENSG00000185811 IKZF1 +-o
ENSG00000161405 IKZF3 -o-
ENSG00000143621 ILF2 o-o
ENSG00000129351 ILF3 -o-
ENSG00000168556 ING2 NonAssociatedWithProgression
ENSG00000213928 IRF9 NonAssociatedWithProgression
ENSG00000177606 JUN NonAssociatedWithProgression
ENSG00000121774 KHDRBS1 NonAssociatedWithProgression
ENSG00000163808 KIF15 NonAssociatedWithProgression
ENSG00000142945 KIF2C o--b
ENSG00000151657 KIN o+o
ENSG00000155090 KLF10 o--b
ENSG00000118922 KLF12 o+o
ENSG00000118263 KLF7 oo-
ENSG00000143815 LBR +oo
ENSG00000138795 LEF1 -o-
ENSG00000105486 LIG1 o--a
ENSG00000005156 LIG3 NonAssociatedWithProgression
ENSG00000174405 LIG4 -+o
ENSG00000143013 LMO4 -+o
ENSG00000099949 LZTR1 o++b
ENSG00000130479 MAP1S o--a
ENSG00000125952 MAX NonAssociatedWithProgression
ENSG00000141644 MBD1 o+o
ENSG00000134046 MBD2 ---
ENSG00000071655 MBD3 o--a
ENSG00000129071 MBD4 o+o
ENSG00000073111 MCM2 o--a
ENSG00000160294 MCM3AP NonAssociatedWithProgression
ENSG00000166508 MCM7 o--b
ENSG00000169057 MECP2 o--a
ENSG00000076242 MLH1 o--b
ENSG00000070444 MNT NonAssociatedWithProgression
ENSG00000103152 MPG o--a
ENSG00000095002 MSH2 +oo
ENSG00000116062 MSH6 o--a
ENSG00000148450 MSRB2 o--a
ENSG00000127989 MTERF o--a
ENSG00000188786 MTF1 o+-
ENSG00000059728 MXD1 NonAssociatedWithProgression
ENSG00000119950 MXI1 +-o
ENSG00000101057 MYBL2 o--b
ENSG00000136997 MYC o--b
ENSG00000104177 MYEF2 NonAssociatedWithProgression
ENSG00000085274 MYNN NonAssociatedWithProgression
ENSG00000102908 NFAT5 o--b
ENSG00000131196 NFATC1 o--b
ENSG00000082641 NFE2L1 NonAssociatedWithProgression
ENSG00000116044 NFE2L2 o--b
ENSG00000050344 NFE2L3 NonAssociatedWithProgression
ENSG00000147862 NFIB NonAssociatedWithProgression
ENSG00000165030 NFIL3 -+o
ENSG00000109320 NFKB1 o++a
ENSG00000077150 NFKB2 NonAssociatedWithProgression
ENSG00000086102 NFX1 NonAssociatedWithProgression
ENSG00000001167 NFYA NonAssociatedWithProgression
ENSG00000120837 NFYB o-o
ENSG00000066136 NFYC NonAssociatedWithProgression
ENSG00000011052 NME2 NonAssociatedWithProgression
ENSG00000130751 NPAS1 NonAssociatedWithProgression
ENSG00000170485 NPAS2 o-+
ENSG00000177463 NR2C2 NonAssociatedWithProgression
ENSG00000113580 NR3C1 o--a
ENSG00000065057 NTHL1 --o
ENSG00000104805 NUCB1 --o
ENSG00000070081 NUCB2 -+o
ENSG00000114026 OGG1 o--a
ENSG00000170515 PA2G4 NonAssociatedWithProgression
ENSG00000143799 PARP1 o--b
ENSG00000102699 PARP4 o+o
ENSG00000007372 PAX6 NonAssociatedWithProgression
ENSG00000169564 PCBP1 NonAssociatedWithProgression
ENSG00000056661 PCGF2 ---
ENSG00000156374 PCGF6 o+o
ENSG00000083642 PDS5B NonAssociatedWithProgression
ENSG00000113068 PFDN1 o-o
ENSG00000112511 PHF1 o--b
ENSG00000100410 PHF5A o--b
ENSG00000116793 PHTF1 o+o
ENSG00000140451 PIF1 ---
ENSG00000181690 PLAG1 oo-
ENSG00000118495 PLAGL1 NonAssociatedWithProgression
ENSG00000126003 PLAGL2 +-o
ENSG00000064933 PMS1 -+o
ENSG00000122512 PMS2 NonAssociatedWithProgression
ENSG00000101868 POLA1 NonAssociatedWithProgression
ENSG00000062822 POLD1 o--a
ENSG00000177084 POLE o--b
ENSG00000051341 POLQ +o+
ENSG00000047315 POLR2B +oo
ENSG00000128513 POT1 o++b
ENSG00000143190 POU2F1 NonAssociatedWithProgression
ENSG00000152192 POU4F1 oo+
ENSG00000102103 PQBP1 ---
ENSG00000164611 PTTG1 NonAssociatedWithProgression
ENSG00000185129 PURA ---
ENSG00000146676 PURB o--a
ENSG00000179262 RAD23A NonAssociatedWithProgression
ENSG00000119318 RAD23B oo-
ENSG00000113522 RAD50 NonAssociatedWithProgression
ENSG00000051180 RAD51 NonAssociatedWithProgression
ENSG00000111247 RAD51AP1 NonAssociatedWithProgression
ENSG00000108384 RAD51C o+-
ENSG00000182185 RAD51L1 ---
ENSG00000185379 RAD51L3 o--b
ENSG00000197275 RAD54B NonAssociatedWithProgression
ENSG00000166349 RAG1 ---
ENSG00000139687 RB1 NonAssociatedWithProgression
ENSG00000003756 RBM5 o-o
ENSG00000004534 RBM6 NonAssociatedWithProgression
ENSG00000153250 RBMS1 o++b
ENSG00000168214 RBPJ o--b
ENSG00000056586 RC3H2 o+o
ENSG00000159200 RCAN1 NonAssociatedWithProgression
ENSG00000173039 RELA o--a
ENSG00000104856 RELB o--b
ENSG00000214022 REPIN1 o--a
ENSG00000135945 REV1 ---
ENSG00000133119 RFC3 -oo
ENSG00000132005 RFX1 ---
ENSG00000087903 RFX2 o-o
ENSG00000080298 RFX3 NonAssociatedWithProgression
ENSG00000117000 RLF o-o
ENSG00000123091 RNF11 o++b
ENSG00000063978 RNF4 NonAssociatedWithProgression
ENSG00000198963 RORB NonAssociatedWithProgression
ENSG00000117748 RPA2 oo-
ENSG00000106399 RPA3 o++b
ENSG00000089009 RPL6 o--b
ENSG00000159216 RUNX1 o--b
ENSG00000020633 RUNX3 o--b
ENSG00000186350 RXRA ---
ENSG00000160633 SAFB o--b
ENSG00000182568 SATB1 o--a
ENSG00000171222 SCAND1 o--a
ENSG00000010803 SCMH1 NonAssociatedWithProgression
ENSG00000047634 SCML1 NonAssociatedWithProgression
ENSG00000102098 SCML2 NonAssociatedWithProgression
ENSG00000125520 SLC2A4RG o-o
ENSG00000175387 SMAD2 NonAssociatedWithProgression
ENSG00000166949 SMAD3 NonAssociatedWithProgression
ENSG00000141646 SMAD4 o--b
ENSG00000127616 SMARCA4 o--b
ENSG00000070366 SMG6 ---
ENSG00000104976 SNAPC2 o--a
ENSG00000164975 SNAPC3 o++b
ENSG00000165684 SNAPC4 o--b
ENSG00000174446 SNAPC5 o++a
ENSG00000103326 SOLH ---
ENSG00000159140 SON NonAssociatedWithProgression
ENSG00000124766 SOX4 +oo
ENSG00000185591 SP1 o--a
ENSG00000135899 SP110 NonAssociatedWithProgression
ENSG00000072310 SREBF1 o--a
ENSG00000149136 SSRP1 o--b
ENSG00000115415 STAT1 oo+
ENSG00000168610 STAT3 o--b
ENSG00000126561 STAT5A o-o
ENSG00000173757 STAT5B ---
ENSG00000166888 STAT6 o--b
ENSG00000113387 SUB1 +-o
ENSG00000213246 SUPT4H1 o--a
ENSG00000109111 SUPT6H o--b
ENSG00000156502 SUPV3L1 o--a
ENSG00000148296 SURF6 NonAssociatedWithProgression
ENSG00000197780 TAF13 o+o
ENSG00000148835 TAF5 o--a
ENSG00000135801 TAF5L +-o
ENSG00000162227 TAF6L ---
ENSG00000120948 TARDBP o--a
ENSG00000137310 TCF19 o-+
ENSG00000141002 TCF25 o-o
ENSG00000101190 TCFL5 o--a
ENSG00000139372 TDG NonAssociatedWithProgression
ENSG00000147601 TERF1 NonAssociatedWithProgression
ENSG00000132604 TERF2 o--a
ENSG00000166848 TERF2IP o--b
ENSG00000108064 TFAM NonAssociatedWithProgression
ENSG00000087510 TFAP2C o--a
ENSG00000090447 TFAP4 o--b
ENSG00000198176 TFDP1 -o-
ENSG00000177426 TGIF1 o+o
ENSG00000126351 THRA --o
ENSG00000092330 TINF2 o--b
ENSG00000198900 TOP1 o+o
ENSG00000131747 TOP2A o--b
ENSG00000197579 TOPORS -o-
ENSG00000141510 TP53 o--a
ENSG00000124496 TRERF1 --o
ENSG00000213689 TREX1 o--b
ENSG00000121060 TRIM25 NonAssociatedWithProgression
ENSG00000234127 TRIM26 +-o
ENSG00000130726 TRIM28 o--a
ENSG00000157514 TSC22D3 +-o
ENSG00000074319 TSG101 NonAssociatedWithProgression
ENSG00000118900 UBN1 o--b
ENSG00000153560 UBP1 o-+
ENSG00000034063 UHRF1 o--b
ENSG00000105698 USF2 ---
ENSG00000141968 VAV1 o--a
ENSG00000084463 WBP11 o--b
ENSG00000198554 WDHD1 ---
ENSG00000165392 WRN +oo
ENSG00000100219 XBP1 -+o
ENSG00000136936 XPA o++b
ENSG00000154767 XPC o--b
ENSG00000152422 XRCC4 o++a
ENSG00000079246 XRCC5 -o-
ENSG00000196419 XRCC6 o--b
ENSG00000065978 YBX1 o--a
ENSG00000127337 YEATS4 o-o
ENSG00000100811 YY1 o--b
ENSG00000116809 ZBTB17 o--b
ENSG00000236104 ZBTB22 o-o
ENSG00000204859 ZBTB48 o--b
ENSG00000186130 ZBTB6 o++b
ENSG00000178951 ZBTB7A o--b
ENSG00000148516 ZEB1 oo-
ENSG00000140836 ZFHX3 o++a
ENSG00000152518 ZFP36L2 NonAssociatedWithProgression
ENSG00000005889 ZFX o--b
ENSG00000165156 ZHX1 NonAssociatedWithProgression
ENSG00000178764 ZHX2 NonAssociatedWithProgression
ENSG00000174306 ZHX3 ---
ENSG00000147130 ZMYM3 --o
ENSG00000146463 ZMYM4 NonAssociatedWithProgression
ENSG00000163867 ZMYM6 +o+
ENSG00000196418 ZNF124 NonAssociatedWithProgression
ENSG00000125846 ZNF133 o++a
ENSG00000196387 ZNF140 NonAssociatedWithProgression
ENSG00000115568 ZNF142 o+-
ENSG00000167635 ZNF146 +o+
ENSG00000204920 ZNF155 o--a
ENSG00000103343 ZNF174 o++b
ENSG00000136870 ZNF189 +o+
ENSG00000186448 ZNF197 +o+
ENSG00000166261 ZNF202 ---
ENSG00000171940 ZNF217 o--b
ENSG00000165804 ZNF219 ---
ENSG00000165512 ZNF22 NonAssociatedWithProgression
ENSG00000179456 ZNF238 o-o
ENSG00000006194 ZNF263 o--a
ENSG00000171606 ZNF274 o--a
ENSG00000165244 ZNF367 NonAssociatedWithProgression
ENSG00000186918 ZNF395 o--a
ENSG00000124459 ZNF45 o+o
ENSG00000075292 ZNF638 o+o
ENSG00000147789 ZNF7 NonAssociatedWithProgression
ENSG00000105750 ZNF85 o+o
ENSG00000132485 ZRANB2 o-+
ENSG00000086827 ZW10 NonAssociatedWithProgression