PEACHi
GeneSet Metabolism of amino acids and derivatives (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o-o -2.8 0.01983 85.0 15.0 7.13
o+o -2.4 0.035 85.0 11.0 5.03
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000151498 ACAD8 o-o
ENSG00000196177 ACADSB oo+
ENSG00000075239 ACAT1 NonAssociatedWithProgression
ENSG00000142920 ADC NonAssociatedWithProgression
ENSG00000182551 ADI1 o--a
ENSG00000183077 AFMID NonAssociatedWithProgression
ENSG00000101444 AHCY o--a
ENSG00000059573 ALDH18A1 o--b
ENSG00000143149 ALDH9A1 o--b
ENSG00000123505 AMD1 o--a
ENSG00000149089 APIP +o+
ENSG00000081181 ARG2 NonAssociatedWithProgression
ENSG00000148090 AUH NonAssociatedWithProgression
ENSG00000155096 AZIN1 NonAssociatedWithProgression
ENSG00000060982 BCAT1 +-o
ENSG00000105552 BCAT2 o--a
ENSG00000248098 BCKDHA o-o
ENSG00000083123 BCKDHB o++a
ENSG00000160200 CBS o--b
ENSG00000171097 CCBL1 NonAssociatedWithProgression
ENSG00000137944 CCBL2 o-o
ENSG00000166165 CKB o-o
ENSG00000116761 CTH o++b
ENSG00000137992 DBT -o-
ENSG00000132437 DDC -oo
ENSG00000091140 DLD NonAssociatedWithProgression
ENSG00000119689 DLST o--a
ENSG00000145293 ENOPH1 NonAssociatedWithProgression
ENSG00000105755 ETHE1 o-o
ENSG00000103876 FAH o-o
ENSG00000130005 GAMT o--b
ENSG00000105607 GCDH NonAssociatedWithProgression
ENSG00000001084 GCLC NonAssociatedWithProgression
ENSG00000023909 GCLM o+o
ENSG00000115419 GLS o--b
ENSG00000148672 GLUD1 o+o
ENSG00000135821 GLUL NonAssociatedWithProgression
ENSG00000120053 GOT1 NonAssociatedWithProgression
ENSG00000125166 GOT2 o--a
ENSG00000137106 GRHPR o-+
ENSG00000100577 GSTZ1 o-o
ENSG00000198130 HIBCH o++b
ENSG00000072506 HSD17B10 o--b
ENSG00000128928 IVD o--a
ENSG00000168906 MAT2A ---
ENSG00000038274 MAT2B o+o
ENSG00000078070 MCCC1 -+o
ENSG00000131844 MCCC2 ---
ENSG00000037757 MRI1 ---
ENSG00000099810 MTAP -o-
ENSG00000116984 MTR NonAssociatedWithProgression
ENSG00000181019 NQO1 NonAssociatedWithProgression
ENSG00000065154 OAT o-o
ENSG00000104904 OAZ1 -o-
ENSG00000180304 OAZ2 o+o
ENSG00000115758 ODC1 o--b
ENSG00000105953 OGDH ---
ENSG00000166228 PCBD1 o++a
ENSG00000092621 PHGDH o--a
ENSG00000135069 PSAT1 +-o
ENSG00000129084 PSMA1 o--a
ENSG00000106588 PSMA2 o+o
ENSG00000100567 PSMA3 o+o
ENSG00000041357 PSMA4 -+o
ENSG00000143106 PSMA5 o--a
ENSG00000100902 PSMA6 NonAssociatedWithProgression
ENSG00000101182 PSMA7 -+o
ENSG00000008018 PSMB1 o-o
ENSG00000126067 PSMB2 oo-
ENSG00000108294 PSMB3 -+o
ENSG00000159377 PSMB4 NonAssociatedWithProgression
ENSG00000100804 PSMB5 o--b
ENSG00000142507 PSMB6 o-o
ENSG00000136930 PSMB7 NonAssociatedWithProgression
ENSG00000204264 PSMB8 o--b
ENSG00000240065 PSMB9 o-o
ENSG00000100764 PSMC1 NonAssociatedWithProgression
ENSG00000161057 PSMC2 o+o
ENSG00000165916 PSMC3 o-o
ENSG00000013275 PSMC4 NonAssociatedWithProgression
ENSG00000087191 PSMC5 -+o
ENSG00000100519 PSMC6 o+o
ENSG00000173692 PSMD1 NonAssociatedWithProgression
ENSG00000101843 PSMD10 o+o
ENSG00000108671 PSMD11 NonAssociatedWithProgression
ENSG00000197170 PSMD12 oo-
ENSG00000185627 PSMD13 o--b
ENSG00000115233 PSMD14 o+o
ENSG00000175166 PSMD2 ---
ENSG00000108344 PSMD3 ---
ENSG00000159352 PSMD4 NonAssociatedWithProgression
ENSG00000095261 PSMD5 o++b
ENSG00000163636 PSMD6 o+o
ENSG00000099341 PSMD8 o--b
ENSG00000110801 PSMD9 o--b
ENSG00000100911 PSME2 NonAssociatedWithProgression
ENSG00000131467 PSME3 o-o
ENSG00000068878 PSME4 o--b
ENSG00000125818 PSMF1 o-+
ENSG00000146733 PSPH ---
ENSG00000183010 PYCR1 o-o
ENSG00000151552 QDPR NonAssociatedWithProgression
ENSG00000130066 SAT1 NonAssociatedWithProgression
ENSG00000176974 SHMT1 o--a
ENSG00000183048 SLC25A10 ---
ENSG00000102743 SLC25A15 NonAssociatedWithProgression
ENSG00000088826 SMOX ---
ENSG00000102172 SMS o-o
ENSG00000137767 SQRDL o++a
ENSG00000116649 SRM o--b
ENSG00000185973 TMLHE -oo
tat_region tat_region oo+