PEACHi
GeneSet IRS-related events (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--a -2.4 0.03389 37.0 11.0 5.26
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000105221 AKT2 o--a
ENSG00000135932 CAB39 +o+
ENSG00000102547 CAB39L -+o
ENSG00000170312 CDK1 o-+
ENSG00000115325 DOK1 o--a
ENSG00000103319 EEF2K o++a
ENSG00000063046 EIF4B o--a
ENSG00000187840 EIF4EBP1 o--b
ENSG00000114867 EIF4G1 ---
ENSG00000077782 FGFR1 o++a
ENSG00000166225 FRS2 NonAssociatedWithProgression
ENSG00000177885 GRB2 NonAssociatedWithProgression
ENSG00000174775 HRAS o--b
ENSG00000171105 INSR +o+
ENSG00000169047 IRS1 o--b
ENSG00000185950 IRS2 NonAssociatedWithProgression
ENSG00000133703 KRAS o+o
ENSG00000169032 MAP2K1 NonAssociatedWithProgression
ENSG00000126934 MAP2K2 o--a
ENSG00000100030 MAPK1 NonAssociatedWithProgression
ENSG00000102882 MAPK3 o--b
ENSG00000167965 MLST8 o--a
ENSG00000198793 MTOR NonAssociatedWithProgression
ENSG00000213281 NRAS o--b
ENSG00000140992 PDPK1 -o-
ENSG00000078142 PIK3C3 o+o
ENSG00000121879 PIK3CA +-o
ENSG00000051382 PIK3CB -o-
ENSG00000145675 PIK3R1 o--a
ENSG00000105647 PIK3R2 o--a
ENSG00000196455 PIK3R4 NonAssociatedWithProgression
ENSG00000100614 PPM1A o--a
ENSG00000132356 PRKAA1 -o-
ENSG00000162409 PRKAA2 o++a
ENSG00000111725 PRKAB1 ---
ENSG00000131791 PRKAB2 NonAssociatedWithProgression
ENSG00000181929 PRKAG1 ---
ENSG00000179295 PTPN11 NonAssociatedWithProgression
ENSG00000132155 RAF1 NonAssociatedWithProgression
ENSG00000106615 RHEB NonAssociatedWithProgression
ENSG00000137154 RPS6 o--a
ENSG00000108443 RPS6KB1 NonAssociatedWithProgression
ENSG00000141564 RPTOR o--a
ENSG00000115904 SOS1 -+o
ENSG00000118046 STK11 o--a
ENSG00000125695 STRADA ---
ENSG00000101255 TRIB3 +-o
ENSG00000165699 TSC1 NonAssociatedWithProgression
ENSG00000103197 TSC2 ---
ENSG00000166913 YWHAB o--b