GeneSet E2F mediated regulation of DNA replication (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o-+ -2.2 0.04333 26.0 3.0 0.75
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000134057 CCNB1 oo-
ENSG00000105173 CCNE1 o--b
ENSG00000164045 CDC25A o--b
ENSG00000093009 CDC45 o++b
ENSG00000094804 CDC6 NonAssociatedWithProgression
ENSG00000170312 CDK1 o-+
ENSG00000228716 DHFR o++a
ENSG00000101412 E2F1 o--b
ENSG00000112029 FBXO5 NonAssociatedWithProgression
ENSG00000125885 MCM8 oo+
ENSG00000085840 ORC1 o+o
ENSG00000115942 ORC2 o++b
ENSG00000135336 ORC3 o+o
ENSG00000115947 ORC4 o+-
ENSG00000164815 ORC5 o+o
ENSG00000091651 ORC6 o--a
ENSG00000132646 PCNA -o-
ENSG00000101868 POLA1 NonAssociatedWithProgression
ENSG00000014138 POLA2 o++b
ENSG00000113575 PPP2CA o--b
ENSG00000104695 PPP2CB +o+
ENSG00000105568 PPP2R1A o--b
ENSG00000137713 PPP2R1B o-+
ENSG00000167393 PPP2R3B o--a
ENSG00000198056 PRIM1 ---
ENSG00000146143 PRIM2 o-+
ENSG00000139687 RB1 NonAssociatedWithProgression
ENSG00000171848 RRM2 o--a
ENSG00000198176 TFDP1 -o-
ENSG00000166548 TK2 o++b
ENSG00000176890 TYMS NonAssociatedWithProgression