PEACHi
GeneSet APC/C-mediated degradation of cell cycle proteins (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
oo- -2.5 0.03156 53.0 4.0 1.01
o+o -3.0 0.01417 53.0 9.0 3.14
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000153107 ANAPC1 o--a
ENSG00000164162 ANAPC10 o++b
ENSG00000141552 ANAPC11 NonAssociatedWithProgression
ENSG00000176248 ANAPC2 NonAssociatedWithProgression
ENSG00000053900 ANAPC4 NonAssociatedWithProgression
ENSG00000089053 ANAPC5 o++a
ENSG00000196510 ANAPC7 o++b
ENSG00000087586 AURKA +-o
ENSG00000178999 AURKB o--b
ENSG00000166167 BTRC --o
ENSG00000156970 BUB1B +oo
ENSG00000154473 BUB3 o--a
ENSG00000145386 CCNA2 o--b
ENSG00000134057 CCNB1 oo-
ENSG00000079335 CDC14A o+o
ENSG00000130177 CDC16 NonAssociatedWithProgression
ENSG00000094880 CDC23 NonAssociatedWithProgression
ENSG00000176386 CDC26 NonAssociatedWithProgression
ENSG00000004897 CDC27 NonAssociatedWithProgression
ENSG00000170312 CDK1 o-+
ENSG00000123374 CDK2 oo-
ENSG00000055130 CUL1 o++a
ENSG00000112029 FBXO5 NonAssociatedWithProgression
ENSG00000164109 MAD2L1 NonAssociatedWithProgression
ENSG00000166851 PLK1 o--a
ENSG00000129084 PSMA1 o--a
ENSG00000106588 PSMA2 o+o
ENSG00000100567 PSMA3 o+o
ENSG00000041357 PSMA4 -+o
ENSG00000143106 PSMA5 o--a
ENSG00000100902 PSMA6 NonAssociatedWithProgression
ENSG00000101182 PSMA7 -+o
ENSG00000008018 PSMB1 o-o
ENSG00000126067 PSMB2 oo-
ENSG00000108294 PSMB3 -+o
ENSG00000159377 PSMB4 NonAssociatedWithProgression
ENSG00000100804 PSMB5 o--b
ENSG00000142507 PSMB6 o-o
ENSG00000136930 PSMB7 NonAssociatedWithProgression
ENSG00000204264 PSMB8 o--b
ENSG00000240065 PSMB9 o-o
ENSG00000100764 PSMC1 NonAssociatedWithProgression
ENSG00000161057 PSMC2 o+o
ENSG00000165916 PSMC3 o-o
ENSG00000013275 PSMC4 NonAssociatedWithProgression
ENSG00000087191 PSMC5 -+o
ENSG00000100519 PSMC6 o+o
ENSG00000173692 PSMD1 NonAssociatedWithProgression
ENSG00000101843 PSMD10 o+o
ENSG00000108671 PSMD11 NonAssociatedWithProgression
ENSG00000197170 PSMD12 oo-
ENSG00000185627 PSMD13 o--b
ENSG00000115233 PSMD14 o+o
ENSG00000175166 PSMD2 ---
ENSG00000108344 PSMD3 ---
ENSG00000159352 PSMD4 NonAssociatedWithProgression
ENSG00000095261 PSMD5 o++b
ENSG00000163636 PSMD6 o+o
ENSG00000099341 PSMD8 o--b
ENSG00000110801 PSMD9 o--b
ENSG00000100911 PSME2 NonAssociatedWithProgression
ENSG00000131467 PSME3 o-o
ENSG00000068878 PSME4 o--b
ENSG00000125818 PSMF1 o-+
ENSG00000164611 PTTG1 NonAssociatedWithProgression
ENSG00000143947 RPS27A o+o
ENSG00000113558 SKP1 ---
ENSG00000145604 SKP2 o++b
ENSG00000221983 UBA52 o--a
ENSG00000170315 UBB ---
ENSG00000175063 UBE2C o-o
ENSG00000072401 UBE2D1 NonAssociatedWithProgression
ENSG00000170142 UBE2E1 o--b