PEACHi
GeneSet Metabolism of nucleotides (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
-+o -2.9 0.01918 37.0 6.0 1.73
o--a -2.4 0.03389 37.0 11.0 5.26
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000196839 ADA -o-
ENSG00000156110 ADK -+o
ENSG00000239900 ADSL -+o
ENSG00000035687 ADSS NonAssociatedWithProgression
ENSG00000185100 ADSSL1 NonAssociatedWithProgression
ENSG00000106992 AK1 NonAssociatedWithProgression
ENSG00000004455 AK2 o--a
ENSG00000116337 AMPD2 NonAssociatedWithProgression
ENSG00000198931 APRT o--b
ENSG00000138363 ATIC o--b
ENSG00000084774 CAD o--a
ENSG00000121691 CAT -+o
ENSG00000162368 CMPK1 NonAssociatedWithProgression
ENSG00000171793 CTPS o-o
ENSG00000156136 DCK ---
ENSG00000129187 DCTD -oo
ENSG00000114956 DGUOK NonAssociatedWithProgression
ENSG00000102967 DHODH NonAssociatedWithProgression
ENSG00000188641 DPYD -+o
ENSG00000168393 DTYMK o-o
ENSG00000128951 DUT o--a
ENSG00000159131 GART NonAssociatedWithProgression
ENSG00000173221 GLRX o+o
ENSG00000100938 GMPR2 -+o
ENSG00000163655 GMPS o--a
ENSG00000233276 GPX1 ---
ENSG00000104687 GSR ---
ENSG00000143774 GUK1 o--a
ENSG00000165704 HPRT1 NonAssociatedWithProgression
ENSG00000106348 IMPDH1 o--a
ENSG00000178035 IMPDH2 o-o
ENSG00000239672 NME1 o--a
ENSG00000011052 NME2 NonAssociatedWithProgression
ENSG00000103202 NME4 --o
ENSG00000125458 NT5C o-o
ENSG00000076685 NT5C2 o--b
ENSG00000122643 NT5C3 NonAssociatedWithProgression
ENSG00000128050 PAICS NonAssociatedWithProgression
ENSG00000178921 PFAS ---
ENSG00000198805 PNP o--a
ENSG00000128059 PPAT NonAssociatedWithProgression
ENSG00000167325 RRM1 o--a
ENSG00000171848 RRM2 o--a
ENSG00000048392 RRM2B -+o
ENSG00000167900 TK1 o--b
ENSG00000166548 TK2 o++b
ENSG00000136810 TXN o++b
ENSG00000198431 TXNRD1 o+o
ENSG00000176890 TYMS NonAssociatedWithProgression
ENSG00000130717 UCK1 o--a
ENSG00000143179 UCK2 +o+
ENSG00000114491 UMPS NonAssociatedWithProgression
ENSG00000183696 UPP1 NonAssociatedWithProgression