GeneSet Loss of proteins required for interphase microtubule organizationfrom the centrosome (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
--o -2.2 0.04176 38.0 4.0 1.17
o+- -2.1 0.04749 38.0 4.0 1.23
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000138107 ACTR1A ---
ENSG00000127914 AKAP9 NonAssociatedWithProgression
ENSG00000116127 ALMS1 NonAssociatedWithProgression
ENSG00000141577 AZI1 ---
ENSG00000170312 CDK1 o-+
ENSG00000136861 CDK5RAP2 o-o
ENSG00000151849 CENPJ o+o
ENSG00000174799 CEP135 +oo
ENSG00000101639 CEP192 o-+
ENSG00000126001 CEP250 o-o
ENSG00000198707 CEP290 -oo
ENSG00000166037 CEP57 NonAssociatedWithProgression
ENSG00000182923 CEP63 NonAssociatedWithProgression
ENSG00000114107 CEP70 NonAssociatedWithProgression
ENSG00000112877 CEP72 +o+
ENSG00000101624 CEP76 o++b
ENSG00000148019 CEP78 NonAssociatedWithProgression
ENSG00000147400 CETN2 o--b
ENSG00000175216 CKAP5 NonAssociatedWithProgression
ENSG00000074054 CLASP1 NonAssociatedWithProgression
ENSG00000141551 CSNK1D o--a
ENSG00000213923 CSNK1E o--b
ENSG00000204843 DCTN1 ---
ENSG00000175203 DCTN2 --o
ENSG00000077380 DYNC1I2 o+o
ENSG00000088986 DYNLL1 --o
ENSG00000213066 FGFR1OP o+-
ENSG00000137814 HAUS2 o-+
ENSG00000080824 HSP90AA1 NonAssociatedWithProgression
ENSG00000101367 MAPRE1 o--b
ENSG00000072864 NDE1 --o
ENSG00000139350 NEDD1 o+o
ENSG00000117650 NEK2 o--b
ENSG00000101004 NINL o--a
ENSG00000136811 ODF2 o--b
ENSG00000046651 OFD1 NonAssociatedWithProgression
ENSG00000007168 PAFAH1B1 o+-
ENSG00000078674 PCM1 o--a
ENSG00000160299 PCNT o--a
ENSG00000166851 PLK1 o--a
ENSG00000142731 PLK4 o+-
ENSG00000105568 PPP2R1A o--b
ENSG00000072062 PRKACA ---
ENSG00000054282 SDCCAG8 ---
ENSG00000198089 SFI1 NonAssociatedWithProgression
ENSG00000176101 SSNA1 NonAssociatedWithProgression
ENSG00000167552 TUBA1A +oo
ENSG00000127824 TUBA4A NonAssociatedWithProgression
ENSG00000196230 TUBB o--a
ENSG00000131462 TUBG1 --o
ENSG00000108953 YWHAE NonAssociatedWithProgression
ENSG00000170027 YWHAG o+-