PEACHi
GeneSet KEGG_DNA_REPLICATION (Pathways_-_KEGGBioCarta.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
AllGenesAssociatedWithProgression -3.3 0.01989 32.0 30.0 23.31
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000138346 DNA2 o++b
ENSG00000168496 FEN1 NonAssociatedWithProgression
ENSG00000105486 LIG1 o--a
ENSG00000073111 MCM2 o--a
ENSG00000104738 MCM4 o--a
ENSG00000100297 MCM5 o--b
ENSG00000076003 MCM6 o--a
ENSG00000166508 MCM7 o--b
ENSG00000132646 PCNA -o-
ENSG00000101868 POLA1 NonAssociatedWithProgression
ENSG00000014138 POLA2 o++b
ENSG00000062822 POLD1 o--a
ENSG00000106628 POLD2 o--b
ENSG00000077514 POLD3 o+o
ENSG00000175482 POLD4 --o
ENSG00000177084 POLE o--b
ENSG00000100479 POLE2 -o-
ENSG00000148229 POLE3 o--a
ENSG00000198056 PRIM1 ---
ENSG00000146143 PRIM2 o-+
ENSG00000035928 RFC1 o--b
ENSG00000049541 RFC2 o--b
ENSG00000133119 RFC3 -oo
ENSG00000163918 RFC4 o--a
ENSG00000111445 RFC5 -oo
ENSG00000171865 RNASEH1 o--b
ENSG00000104889 RNASEH2A o--b
ENSG00000136104 RNASEH2B o--a
ENSG00000172922 RNASEH2C o--b
ENSG00000117748 RPA2 oo-
ENSG00000106399 RPA3 o++b
ENSG00000106028 SSBP1 o++b