GeneSet ISG15 antiviral mechanism (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o+- -2.5 0.03236 46.0 5.0 1.49
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000094914 AAAS o--a
ENSG00000166233 ARIH1 o--a
ENSG00000055332 EIF2AK2 o--a
ENSG00000161960 EIF4A1 -o-
ENSG00000156976 EIF4A2 o+o
ENSG00000141543 EIF4A3 NonAssociatedWithProgression
ENSG00000135930 EIF4E2 o--a
ENSG00000163412 EIF4E3 o++b
ENSG00000114867 EIF4G1 ---
ENSG00000110321 EIF4G2 o+-
ENSG00000075151 EIF4G3 NonAssociatedWithProgression
ENSG00000136068 FLNB NonAssociatedWithProgression
ENSG00000138646 HERC5 +-o
ENSG00000126456 IRF3 o--a
ENSG00000187608 ISG15 o-+
ENSG00000162434 JAK1 o--b
ENSG00000114030 KPNA1 NonAssociatedWithProgression
ENSG00000182481 KPNA2 o--a
ENSG00000102753 KPNA3 NonAssociatedWithProgression
ENSG00000186432 KPNA4 NonAssociatedWithProgression
ENSG00000196911 KPNA5 NonAssociatedWithProgression
ENSG00000108424 KPNB1 o--a
ENSG00000102882 MAPK3 o--b
ENSG00000183486 MX2 NonAssociatedWithProgression
ENSG00000069869 NEDD4 -+o
ENSG00000111581 NUP107 -+o
ENSG00000069248 NUP133 o+-
ENSG00000124789 NUP153 o+-
ENSG00000113569 NUP155 NonAssociatedWithProgression
ENSG00000030066 NUP160 NonAssociatedWithProgression
ENSG00000095319 NUP188 ---
ENSG00000155561 NUP205 -o-
ENSG00000132182 NUP210 o-o
ENSG00000126883 NUP214 NonAssociatedWithProgression
ENSG00000163002 NUP35 oo-
ENSG00000075188 NUP37 NonAssociatedWithProgression
ENSG00000093000 NUP50 NonAssociatedWithProgression
ENSG00000138750 NUP54 o-o
ENSG00000213024 NUP62 o--a
ENSG00000125450 NUP85 o--b
ENSG00000108559 NUP88 NonAssociatedWithProgression
ENSG00000102900 NUP93 o-o
ENSG00000110713 NUP98 o--a
ENSG00000139496 NUPL1 +-o
ENSG00000136243 NUPL2 o+-
ENSG00000127445 PIN1 o-o
ENSG00000196313 POM121 o--b
ENSG00000138032 PPM1B o-o
ENSG00000101146 RAE1 -o-
ENSG00000153201 RANBP2 o+o
ENSG00000143947 RPS27A o+o
ENSG00000085415 SEH1L o-o
ENSG00000115415 STAT1 oo+
ENSG00000047410 TPR o+-
ENSG00000121060 TRIM25 NonAssociatedWithProgression
ENSG00000221983 UBA52 o--a
ENSG00000170315 UBB ---
ENSG00000170142 UBE2E1 o--b
ENSG00000156587 UBE2L6 oo+
ENSG00000177889 UBE2N o--a
gag_region gag_region oo+