PEACHi
GeneSet HIV_human_PPI_VPR (HIV_Collection.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o-o -3.7 0.01349 32.0 9.0 2.68
DownRegulated -2.7 0.02047 32.0 26.0 18.9
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000135776 ABCB10 o++b
ENSG00000117528 ABCD3 NonAssociatedWithProgression
ENSG00000107897 ACBD5 o--b
ENSG00000018510 AGPS ---
ENSG00000131503 ANKHD1 o--b
ENSG00000076513 ANKRD13A o-o
ENSG00000132466 ANKRD17 ---
ENSG00000108588 CCDC47 o++b
ENSG00000143702 CEP170 NonAssociatedWithProgression
ENSG00000093010 COMT NonAssociatedWithProgression
ENSG00000166200 COPS2 o--b
ENSG00000141030 COPS3 o--b
ENSG00000138663 COPS4 o+o
ENSG00000121022 COPS5 NonAssociatedWithProgression
ENSG00000168090 COPS6 ---
ENSG00000198612 COPS8 NonAssociatedWithProgression
ENSG00000139842 CUL4A oo-
ENSG00000100897 DCAF11 o-o
ENSG00000132716 DCAF8 o-o
ENSG00000130311 DDA1 o--b
ENSG00000167986 DDB1 o--a
ENSG00000064703 DDX20 NonAssociatedWithProgression
ENSG00000173852 DPY19L1 -+o
ENSG00000178904 DPY19L3 NonAssociatedWithProgression
ENSG00000077380 DYNC1I2 o+o
ENSG00000144635 DYNC1LI1 o--a
ENSG00000152147 GEMIN6 o+o
ENSG00000142252 GEMIN7 o--b
ENSG00000113384 GOLPH3 o-o
ENSG00000169727 GPS1 ---
ENSG00000128708 HAT1 NonAssociatedWithProgression
ENSG00000015479 MATR3 -o-
ENSG00000115275 MOGS o-o
ENSG00000109919 MTCH2 o-o
ENSG00000110717 NDUFS8 o--a
ENSG00000131467 PSME3 o-o
ENSG00000102054 RBBP7 o-o
ENSG00000172062 SMN1 NonAssociatedWithProgression
ENSG00000205571 SMN2 NonAssociatedWithProgression
ENSG00000178307 TMEM11 ---
ENSG00000130748 TMEM160 o-o
ENSG00000078246 TULP3 o--a