GeneSet FRS2-mediated cascade (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--b -2.4 0.03389 9.0 4.0 1.24
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000170312 CDK1 o-+
ENSG00000077782 FGFR1 o++a
ENSG00000166225 FRS2 NonAssociatedWithProgression
ENSG00000177885 GRB2 NonAssociatedWithProgression
ENSG00000174775 HRAS o--b
ENSG00000133703 KRAS o+o
ENSG00000169032 MAP2K1 NonAssociatedWithProgression
ENSG00000126934 MAP2K2 o--a
ENSG00000100030 MAPK1 NonAssociatedWithProgression
ENSG00000102882 MAPK3 o--b
ENSG00000213281 NRAS o--b
ENSG00000179295 PTPN11 NonAssociatedWithProgression
ENSG00000132155 RAF1 NonAssociatedWithProgression
ENSG00000115904 SOS1 -+o
ENSG00000166913 YWHAB o--b