PEACHi
GeneSet Downstream signal transduction (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
-o- -2.2 0.04546 50.0 5.0 1.7
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000138031 ADCY3 o-o
ENSG00000121281 ADCY7 -+o
ENSG00000173020 ADRBK1 o--b
ENSG00000142208 AKT1 ---
ENSG00000204673 AKT1S1 ---
ENSG00000105221 AKT2 o--a
ENSG00000117020 AKT3 o++b
ENSG00000198668 CALM1 NonAssociatedWithProgression
ENSG00000152495 CAMK4 +-o
ENSG00000170312 CDK1 o-+
ENSG00000124762 CDKN1A oo-
ENSG00000111276 CDKN1B +o+
ENSG00000213341 CHUK NonAssociatedWithProgression
ENSG00000118260 CREB1 o+-
ENSG00000167193 CRK o+o
ENSG00000099942 CRKL o--b
ENSG00000118689 FOXO3 NonAssociatedWithProgression
ENSG00000184481 FOXO4 --o
ENSG00000177885 GRB2 NonAssociatedWithProgression
ENSG00000105723 GSK3A ---
ENSG00000082701 GSK3B -o-
ENSG00000174775 HRAS o--b
ENSG00000150995 ITPR1 o++b
ENSG00000096433 ITPR3 o-o
ENSG00000133703 KRAS o+o
ENSG00000169032 MAP2K1 NonAssociatedWithProgression
ENSG00000126934 MAP2K2 o--a
ENSG00000100030 MAPK1 NonAssociatedWithProgression
ENSG00000102882 MAPK3 o--b
ENSG00000119487 MAPKAP1 o--a
ENSG00000135679 MDM2 -o-
ENSG00000167965 MLST8 o--a
ENSG00000198793 MTOR NonAssociatedWithProgression
ENSG00000158092 NCK1 o+-
ENSG00000071051 NCK2 o--b
ENSG00000213281 NRAS o--b
ENSG00000123360 PDE1B o-+
ENSG00000140992 PDPK1 -o-
ENSG00000081913 PHLPP1 NonAssociatedWithProgression
ENSG00000121879 PIK3CA +-o
ENSG00000051382 PIK3CB -o-
ENSG00000145675 PIK3R1 o--a
ENSG00000105647 PIK3R2 o--a
ENSG00000072062 PRKACA ---
ENSG00000142875 PRKACB o--b
ENSG00000108946 PRKAR1A o+-
ENSG00000188191 PRKAR1B NonAssociatedWithProgression
ENSG00000154229 PRKCA oo+
ENSG00000163932 PRKCD NonAssociatedWithProgression
ENSG00000171862 PTEN NonAssociatedWithProgression
ENSG00000179295 PTPN11 NonAssociatedWithProgression
ENSG00000132155 RAF1 NonAssociatedWithProgression
ENSG00000107263 RAPGEF1 NonAssociatedWithProgression
ENSG00000145715 RASA1 NonAssociatedWithProgression
ENSG00000164327 RICTOR o--b
ENSG00000175634 RPS6KB2 -o-
ENSG00000115904 SOS1 -+o
ENSG00000115415 STAT1 oo+
ENSG00000168610 STAT3 o--b
ENSG00000126561 STAT5A o-o
ENSG00000173757 STAT5B ---
ENSG00000166888 STAT6 o--b
ENSG00000101255 TRIB3 +-o
ENSG00000103197 TSC2 ---
ENSG00000166913 YWHAB o--b