GeneSet Apoptotic execution phase (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o--b -2.2 0.04349 26.0 8.0 3.59
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000100813 ACIN1 ---
ENSG00000087274 ADD1 +o+
ENSG00000134982 APC NonAssociatedWithProgression
ENSG00000185825 BCAP31 ---
ENSG00000110330 BIRC2 NonAssociatedWithProgression
ENSG00000164305 CASP3 o++b
ENSG00000138794 CASP6 o++b
ENSG00000165806 CASP7 o-o
ENSG00000064012 CASP8 +-o
ENSG00000168036 CTNNB1 o--b
ENSG00000136279 DBNL o--a
ENSG00000160049 DFFA NonAssociatedWithProgression
ENSG00000087470 DNM1L NonAssociatedWithProgression
ENSG00000046604 DSG2 NonAssociatedWithProgression
ENSG00000096696 DSP NonAssociatedWithProgression
ENSG00000168522 FNTA o-o
ENSG00000189060 H1F0 o--b
ENSG00000187837 HIST1H1C o--b
ENSG00000124575 HIST1H1D ---
ENSG00000189403 HMGB1 o--b
ENSG00000164104 HMGB2 o--b
ENSG00000114030 KPNA1 NonAssociatedWithProgression
ENSG00000108424 KPNB1 o--a
ENSG00000113368 LMNB1 o--b
ENSG00000186868 MAPT o++a
ENSG00000180370 PAK2 ---
ENSG00000081277 PKP1 NonAssociatedWithProgression
ENSG00000178209 PLEC o--a
ENSG00000163932 PRKCD NonAssociatedWithProgression
ENSG00000065675 PRKCQ o+o
ENSG00000067900 ROCK1 o+o
ENSG00000182568 SATB1 o--a
ENSG00000197694 SPTAN1 NonAssociatedWithProgression
ENSG00000102572 STK24 o--b
ENSG00000119139 TJP2 o++b
ENSG00000026025 VIM o--b