GeneSet TRAF6 mediated IRF7 activation (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o++b -2.8 0.01969 12.0 4.0 0.96
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000005339 CREBBP NonAssociatedWithProgression
ENSG00000100393 EP300 o++b
ENSG00000143466 IKBKE ---
ENSG00000125347 IRF1 o+o
ENSG00000168310 IRF2 o++b
ENSG00000126456 IRF3 o--a
ENSG00000185507 IRF7 ---
ENSG00000088888 MAVS --o
ENSG00000181481 RNF135 --o
ENSG00000052723 SIKE1 o++b
ENSG00000136560 TANK o+o
ENSG00000183735 TBK1 o++b
ENSG00000127191 TRAF2 o--b
ENSG00000175104 TRAF6 NonAssociatedWithProgression
ENSG00000121060 TRIM25 NonAssociatedWithProgression