GeneSet HIV Nef mediated downregulation of MHC class I complex cell surface expression (HIV_Collection.gmt.txt) is enriched in the following clusters
| Cluster | log(P) | Qvalue | Observed in Background | Observed in Cluster | Expected in Cluster |
|---|---|---|---|---|---|
| AllGenesAssociatedWithProgression | -1.7976931348623157E308 | 0.0 | 8.0 | 8.0 | 5.83 |
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at
three phases of the viral life cycle, namely reverse transcription, integration, and late phase.
Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering.
Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
| Ensembl ID | Name | Cluster |
|---|---|---|
| ENSG00000100280 | AP1B1 | o--b |
| ENSG00000166747 | AP1G1 | o+- |
| ENSG00000072958 | AP1M1 | o--b |
| ENSG00000106367 | AP1S1 | --- |
| ENSG00000182287 | AP1S2 | -+o |
| ENSG00000166710 | B2M | o+o |
| ENSG00000206503 | HLA-A | +-o |
| ENSG00000175115 | PACS1 | --- |