GeneSet E2F-enabled inhibition of pre-replication complex formation (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o+o -2.7 0.02225 10.0 3.0 0.59
AllGenesAssociatedWithProgression -1.7976931348623157E308 0.0 10.0 10.0 7.29
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000134057 CCNB1 oo-
ENSG00000164045 CDC25A o--b
ENSG00000170312 CDK1 o-+
ENSG00000125885 MCM8 oo+
ENSG00000085840 ORC1 o+o
ENSG00000115942 ORC2 o++b
ENSG00000135336 ORC3 o+o
ENSG00000115947 ORC4 o+-
ENSG00000164815 ORC5 o+o
ENSG00000091651 ORC6 o--a