GeneSet Activation of ATR in response to replication stress (Pathways_-_Reactome.gmt.txt) is enriched in the following clusters
Cluster log(P) Qvalue Observed in Background Observed in Cluster Expected in Cluster
o+o -2.4 0.035 27.0 5.0 1.6
Gene expression pattern
Figure: Temporal expression patterns were grouped into clusters with differential expression profiles at three phases of the viral life cycle, namely reverse transcription, integration, and late phase. Boxplots on the left show the distribution of the normalized regression weights for each viral phase used in clustering. Expression change pattern of each gene over time is plotted for mock and HIV samples (dotted orange lines) along with the cluster median (bold red line).
List of genes
Ensembl ID Name Cluster
ENSG00000175054 ATR NonAssociatedWithProgression
ENSG00000164053 ATRIP NonAssociatedWithProgression
ENSG00000164045 CDC25A o--b
ENSG00000158402 CDC25C o-+
ENSG00000093009 CDC45 o++b
ENSG00000094804 CDC6 NonAssociatedWithProgression
ENSG00000097046 CDC7 NonAssociatedWithProgression
ENSG00000123374 CDK2 oo-
ENSG00000149554 CHEK1 o+o
ENSG00000006634 DBF4 ---
ENSG00000136273 HUS1 o+o
ENSG00000065328 MCM10 NonAssociatedWithProgression
ENSG00000073111 MCM2 o--a
ENSG00000104738 MCM4 o--a
ENSG00000100297 MCM5 o--b
ENSG00000076003 MCM6 o--a
ENSG00000166508 MCM7 o--b
ENSG00000125885 MCM8 oo+
ENSG00000085840 ORC1 o+o
ENSG00000115942 ORC2 o++b
ENSG00000135336 ORC3 o+o
ENSG00000115947 ORC4 o+-
ENSG00000164815 ORC5 o+o
ENSG00000091651 ORC6 o--a
ENSG00000113456 RAD1 NonAssociatedWithProgression
ENSG00000152942 RAD17 o--a
ENSG00000172613 RAD9A o--b
ENSG00000049541 RFC2 o--b
ENSG00000133119 RFC3 -oo
ENSG00000163918 RFC4 o--a
ENSG00000111445 RFC5 -oo
ENSG00000117748 RPA2 oo-
ENSG00000106399 RPA3 o++b